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电刺激左右侧迷走神经对感染性休克大鼠血压肝功能的保护作用

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on system. Stimuli with constant voltage (5 V, 2 ms, 1 Hz) were applied to the nerve for 20 minutes immediately after the models were operated. Before stimulation the common carotid artery was implanted into a blood pressure transducer for continuous registration of mean arterial blood pressure (MAP).Blood samples of these rats were collected at 2 h after stimulation in all groups to detect TNF (tumor necrosis factors)α levels of the homogenate in liver, aspartate aminotransferase (AST) and ALT (alanine transaminase) levels in serum.Results  The MAP gradually decreased and the concentration of TNFα levels of the homogenate in liver, AST and ALT levels in serum significantly increased after cecal ligation and puncture. Electrical stimulation of the left and right efferent vagus nerve significantly increased the MAP and attenuated TNFα levels of the homogenate in liver, AST and ALT levels in blood serum.
Conclusions  Direct electrical stimulation of the peripheral left and right vagus nerve can significantly decrease blood pressure and reduce TNFα levels of the homogenate in liver, AST and ALT levels in serum during septic shock. It might produce a potential protective effect on liver function of septic shock in rats, and there is no difference between the left and right vagus nerve after electrical stimulation.
   
　　【Key words】  Vagus nerve; Electrical stimulation; Septic shock; Tumor necrosis factorsα

　　近年对胆碱能抗炎通路的研究表明：神经系统和免疫系统之间存在着一条由迷走神经及其释放的递质乙酰胆碱为主构成的抗炎通路。该通路激活后可能对预防和拮抗感染性休克发病进程中过度的全身性炎性反应有重要作用〔1～3〕。为了避免心脏方面的副作用，电刺激常选择左侧迷走神经刺激术（左侧迷走神经支配房室结功能，右侧支配窦房结功能），而电刺激右侧迷走神经却少见报道。但左、右侧迷走神经的解剖路径有所不同，两侧迷走神经兴奋对胆碱能抗炎通路的激活效应是否有所差异，对其可行性及其机制的阐明有助于未来胆碱能抗炎通路激活

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