神经元烯醇化酶在肺癌中的临床意义

【摘要】  探讨肺癌患者血清神经元烯醇化酶(NSE)的临床价值。［方法］ 采用放射免疫法检测374例肺癌患者、161例肺良性病变和158例正常对照组的血清NSE水平。［结果］ 肺癌患者血清NSE水平显著性高于肺癌良性疾病患者和正常对照组（P<0.01）,小细胞肺癌血清NSE水平为最高。NSE水平随分期升高而增高， Ⅳ/Ⅲ期病人NSE水平显著高于Ⅰ/Ⅱ期病人（P<0.01）。NSE水平低的病人预后相对较好。 ［结论］ NSE可作为一种有效的肺癌肿瘤标志物。

【关键词】  肺肿瘤

    Clinical Value of Serum Neuron Specific Enolase in Lung Cancer

    Abstract: ［Purpose］ To investigate the clinical value of serum neuron specific enolase (NSE) in lung cancer. ［Methods］ The serum level of NSE in 374 cases with lung cancer, 161 cases with benign pulmonary disease and 158 healthy controls was detected by radioimmunoassay. ［Results］ The serum NSE in patients with lung cancer was significantly higher than that in patients with benign lung disease and healthy controls (P<0.01). The serum NSE level in small-cell lung cancer  was the highest, and increased with staging increase in the lung cancer. The serum NSE level in stage Ⅳ/Ⅲ was significantly higher than that in stageⅠ/Ⅱ（P<0.01）. The prognosis in patients with low level NSE was superior to those with high level NSE. ［Conclusions］ NSE may be used as a useful tumor marker in patients with lung cancer.

    Key words: lung neoplasms; NSE; radioimmunoassay

    神经元烯醇化酶(neuron specific enolase，NSE)被认为是小细胞肺癌的标志物，对小细胞肺癌的诊断有很大的意义，但国内对其在非小细胞肺癌的研究较少。本文检测各种类型肺癌和常见良性肺部疾病的NSE的水平，探讨NSE水平对肺癌的诊断、治疗和预后评价的意义。

    1   材料与方法

    1.1   临床资料

    1996~2004年在本院就诊的住院及门诊肺癌患者374例，其中男性226例，女性148例，年龄21岁~94岁，中位年龄65岁；鳞癌76例，腺癌106例，小细胞肺癌(SCLC)33例，未分型肺癌159例。根据1997年国际抗癌联盟