蓖麻毒素毒性作用机理研究进展

      三、总结和展望

　　蓖麻毒素的毒性具有明显的剂量依赖性，毒素诱导细胞因子的产生，引起体内脂质过氧化损伤以及诱导靶细胞凋亡等等都是在小剂量范围内具有的，而大剂量的蓖麻毒素仍主要表现为抑制蛋白质合成的毒性。毒素诱导细胞因子的产生及引起体内脂质过氧化损伤的作用，均与其糖链末端甘露糖残基被巨噬细胞特异性摄取，并激活巨噬细胞有关，是毒素损伤的继发作用。蓖麻毒素等蛋白质合成抑制剂诱导凋亡的理论研究对现有的凋亡理论可能会有重要的补充价值。

　　蓖麻毒素的毒性作用机理研究，特别是近几年的研究进展，丰富了人们对蓖麻毒素毒性作用的认识，为蓖麻毒素抗癌研究进一步提供了理论依据和新的思路。

　　本课题受国家自然科学基金资助(编号：39500122)

　　作者单位：710032 西安市 第四军医大学毒理学教研室

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